![]() Responses were evaluated after three courses by the integrated FDG-PET/IWC criteria, and reassessed at the end of the entire program. Treatment was given every two weeks with G-CSF support (5 mcg/kg/day, dd 6–11 10 mcg/kg/day at the 3rd course for stem cells mobilization). R-GIFOX consisted of R (375 mg/m2, d 1), G (1000 mg/m2, d 2), Ox (130 mg/m2, d 3) and Ifo (5 g/m2, d 3), as a 24-hour single infusion in patients aged ≤ 65 years, or fractionated over 3 days (dd 3–5) in older patients. Therapy was delivered on a compassionate basis after written informed consent. ![]() Patients and methods: Patients were scheduled to receive three courses of therapy followed by mobilization and ASCT or three more courses if ineligible for ASCT. Based on the predicted clinical activity, tolerability and synergy among drugs, the R-GIFOX regimen may offer an effective and less toxic alternative to Cisplatin/ARA-C-based salvage regimens, also for patients aged or unfit for high-dose procedures. (Failure sending mail.Objective: In this pilot study we evaluated the clinical activity, toxicity and mobilizing capacity of a new short-course (bi-weekly), dose intensive, cytoreductive/mobilizing salvage regimen (R-GIFOX) combining the cross-synergistic agents Gemcitabine (G), Ifosfamide (Ifo), Oxaliplatin (Ox) and Rituximab (R), in patients with relapsed and refractory CD20 NHL. 16:58:43,Warning,110238,Cannot send mails to mail server. ![]() 16:58:43,Warning,110239,Cannot send mails to mail server. 16:58:43,Warning,110240,Cannot send mails to mail server. 16:58:50,Warning,110241,Cannot send mails to mail server. Exception Message: Cannot send mails to mail server. Sending Mail using Account 2 (T17:30:22). (Sending Mail using Account 1 (T17:28:42). 17:30:22,Error,110246,The mail could not be sent to the recipients because of the mail server failure. 17:30:22,Error,110247,The mail could not be sent to the recipients because of the mail server failure. Sending Mail using Account 2 (T17:34:42). (Sending Mail using Account 1 (T17:33:02). 17:34:42,Error,110248,The mail could not be sent to the recipients because of the mail server failure. Sending Mail using Account 2 (T17:35:22). (Sending Mail using Account 1 (T17:33:42). 17:35:22,Error,110249,The mail could not be sent to the recipients because of the mail server failure. Sending Mail using Account 2 (T17:39:42). (Sending Mail using Account 1 (T17:38:02). 17:39:42,Error,110250,The mail could not be sent to the recipients because of the mail server failure. 17:47:22,Error,110251,1) Exception Information=Exception Type: .: The Transaction not longer valid.Data: : Void ValidateConnectionAndTransaction()HelpLink: NULLSource: DatabaseMailEngineStackTrace Information= at .() at .() at .(DataAccessAdapter da Int32 lifetimeMinimumSec) at .(String dbName String dbServerName Int32 lifetimeMinimumSec LogLevel loggingLevel),17884, 5:47:22 PM,NT AUTHORITY\SYSTEM Database mail ran fine for several months then started doing this a couple of times a day. I then have to start/stop/start to get mail running again. ![]() I have to use task-manager to kill databasemail90 to get it to end. Database mail will run fine for hours then stops sending with the error listed below.
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